In order for an in vitro system to be most useful it should best mimic the in vivo tissue. For this reason 3D cell culture approaches have become more prevalent and have proven to exhibit fewer misleading results than their 2D counterparts.
The scientists at InvivoSciences have recognized the importance of using 3D cultures for drug assessment and have met the challenge of creating a suitable in vitro system with their Mini-Construct ChambersTM .
The CLARIOstar® captures periodic Ca2+-transients
that induce cardiac contractions
Together, BMG and InvivoSciences can provide a platform for the analysis of drug effects on heart function and do so at the early of stages drug discovery!
BMG LABTECH Application Note 253: Real time calcium flux measurements in iPSC derived 3D heart tissues.