|Photograph of CSHL in the fall of 2008|
The group used Scalpel on a genome database produced from families in which one child suffered from autism and the rest of the family is unaffected. This approach allowed them to identify indels that likely disupt genes in autistic children.
The scientist are now seeking to apply Scalpel more broadly and are collaborating with any scientists, such as cancer biologists, that are looking for indels.
Some material for this post was obtained from the Science Daily article: A shift in the code: New method reveals hidden genetic landscape
Original Article citation: Giuseppe Narzisi, Jason A O'Rawe, Ivan Iossifov, Han Fang, Yoon-ha Lee, Zihua Wang, Yiyang Wu, Gholson J Lyon, Michael Wigler, Michael C Schatz. Accurate de novo and transmitted indel detection in exome-capture data using microassembly. Nature Methods, 2014