|DHFR with dihydrofolate (left) |
and NADPH (right) bound
The results of the current paper showed that although bacteria and human DHFR are different in terms of genetic and protein sequence, the chemical conversion performed by this enzyme is quite well conserved. Indeed the bacterial enzyme already has reactants perfectly aligned in its active site! This was quite surprising as the human enzyme is not only genetically different but much faster.
The results of this work are important in the design of drugs against DHFR and the design of catalysts that are inspired by nature.
Some information for this blog was obtained from: 'Evolution On Molecular Level'