Now, a recent article in Science explains an approach that does not require macroscopic crystals and can generate a 3-D structure without prior structural knowledge. The results of a collaboration between German and U.S. scientist are reported in the article entitled: 'De novo protein crystal structure determination from X-ray free-electron laser data'. In this article, the authors describe an approach which uses nanometer to micrometer sized crystals which are in a complex with a lanthanide compound, in this case gadolinium.
|Single Protein crystal of Lysozyme |
Photographed by Mathias Klode
New technique does not require a macroscopic crystal such as this