|Salt deposit at Dead Sea|
The origin-less replication occurred at dispersed sites rather than discrete origins and in order to perform this origin-less replication Haloferax volcanii adapted another cellular function, homologous recombination, to initiate DNA replication. In fact, they found that the recombinase RadA was absolutely essential for replication in the absence of origins.
The unregulated and accelerated growth of the origin-less Haloferax volcanii strain can be compared to cancer cells. It is the hope of the authors of this study that by better understanding the phenomena they observed they may shed light on how cancer cells avoid normal controls and this understanding could lead to new targets to selectively effect cancer cells.