|Bovine prion protein residues 23-230|
Lopez-Garcia, F., Zahn, R., Riek, R., Wuthrich, K. & RCSB
With all the excellent posters and talks it is difficult to say something about each but one of the highlights was Stefanie Czub’s presentation entitled: ‘BSE: what else is new’. Stefanie presented some excellent video documentation of the degenerative effects of atypical forms of BSE that she is investigating at the University of Calgary. This launched a great discussion about when these atypical forms are present and the role of cattle breed in the observed effects.
Another extremely interesting presentation was given by Joel Watts a post-doctoral fellow in Stanley Prussiner's lab at UCSF. Most species have what is referred to as a species barrier; the inability to be affected by most of the disease causing prions (PrPsc) from a different species. One of the few known exceptions to this is the bank vole which can develop disease when challenged by most species PrPsc. They mutated mouse PrPsc to match that of bank vole PrPsc. Despite this involving only changing 8 amino acids this was sufficient to provide susceptibility to PrPsc from all species tested.
BMG LABTECH is very much looking forward to the remainder of the conference especially the presentation by Stanley Prussiner, Nobel laureate. Thank you all for such a great conference!