|PrPsc induces conformational change in PrPc|
A recent paper in the Journal of Biological Chemistry has studied two forms of mouse prion protein that are polymorphic at amino acid residues 108/189. The results have implications in understanding disease susceptibility and species barriers.
The group from University of Alberta found that the recombinant forms of the two prion protein differed with respect to aggregation and response to seeding in an in vitro kinetic assay.
Paper title: Mouse Prion Protein Polymorphism Phe-108/Val-189 Affects the Kinetics of Fibril Formation and the Response to Seeding EVIDENCE FOR A TWO-STEP NUCLEATION POLYMERIZATION MECHANISM*