|Two NOD/SCID mice expressing enhanced green fluorescent|
protein (eGFP) under UV-illumination flanking one plain
NOD/SCID mouse from the non-transgenic parental line
The failure to find effective drug treatments for these conditions is believed to stem from the lack of similarity between mouse and human responses. Nearly 150 drugs for sepsis have been tested in humans based on results from mice and all have failed. However, there is hope that since we now know that the human response to burns, trauma or sepsis are similar that a drug that aids with one will aid with the others.
By no means is this the end of mice as an animal model. There are too many cases to innumerate where they have been effective. In the end we must remember that the goal is to cure humans and not mice.
For more information see this article from the NY Times: Mice Fall Short as Test Subjects for Humans’ Deadly Ills